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Klra8Cmv1-del
Allele Detail
Nomenclature
Symbol: Klra8Cmv1-del
Name: killer cell lectin-like receptor, subfamily A, member 8; cytomegalovirus resistance 1, deletion
MGI ID: MGI:3773165
Synonyms: Klra8KO, L49h-
Gene: Klra8  Location: Chr6:130115226-130129898 bp, - strand  Genetic Position: Chr6, 63.44 cM
Mutation
origin
Strain of Origin:  BXD8/TyJ
Mutation
description
Allele Type:    Not Applicable
Mutation:    Intragenic deletion
 
Mutation detailsMapping experiments identified a 23 kb deletion in the Klra cluster in the BXD-8/Ty strain that contained only the Klra8 gene. This deletion correlated with an increased susceptiblity to cytomegalovirus infection. (J:79093)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Klra8 Mutation:  12 strains or lines available
References
Original:  J:79093 Lee SH, et al., Susceptibility to mouse cytomegalovirus is associated with deletion of an activating natural killer cell receptor of the C-type lectin superfamily. Nat Genet. 2001 May;28(1):42-5
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory