Klra8^Cmv1-del
Allele Detail

Summary

• Symbol: Klra8^Cmv1-del
• Name: killer cell lectin-like receptor, subfamily A, member 8; cytomegalovirus resistance 1, deletion
• MGI ID: MGI:3773165
• Synonyms: Klra8^KO, L49h^-
• Gene: Klra8 Location: Chr6:130092189-130106861 bp, - strand Genetic Position: Chr6, 63.44 cM
• Alliance: Klra8^Cmv1-del page

Mutation origin

• Strain of Origin: BXD8/TyJ

Mutation description

• Allele Type: Not Applicable
• Mutation: Intragenic deletion
• Mutation details: Mapping experiments identified a 23 kb deletion in the Klra cluster in the BXD-8/Ty strain that contained only the Klra8 gene. This deletion correlated with an increased susceptiblity to cytomegalovirus infection. (J:79093)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Klra8 Mutation: 18 strains or lines available

References

• Original: J:79093 Lee SH, et al., Susceptibility to mouse cytomegalovirus is associated with deletion of an activating natural killer cell receptor of the C-type lectin superfamily. Nat Genet. 2001 May;28(1):42-5
• All: 37 reference(s)