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Tg(Nkx2-1-cre)2Sand
Transgene Detail
Nomenclature
Symbol: Tg(Nkx2-1-cre)2Sand
Name: transgene insertion 2, Stewart Anderson
MGI ID: MGI:3773076
Synonyms: Nkx2-1BACCre, Nkx2.1-cre, NKX2.1Cre, Tg(Nkx2-1-cre)1Qixu, Tg(Nkx2-1-cre)2Qixu, Ttf-1Cre
Transgene: Tg(Nkx2-1-cre)2Sand  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Mutation detailsA mouse BAC clone containing the Nkx2-1 gene was engineered to express cre recombinase. Fifteen base pairs at the 5'end of exon 2 of the Nkx2-1 gene were replaced with a cre-poly(A) construct. The mutated BAC clone was then used to generate transgenic mice. This construct is expressed in brain, thyroid, pituitary, and lung, with telecephalic expression first detectable at E10.5. (J:131144)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Nkx2-1     Summary of all recombinase alleles driven by Nkx2-1.
 

Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 46 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:131144 Xu Q, et al., Fate mapping Nkx2.1-lineage cells in the mouse telencephalon. J Comp Neurol. 2008 Jan 1;506(1):16-29
All:  39 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory