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Targeted Allele Detail
Symbol: Kittm1Shta
Name: kit oncogene; targeted mutation 1, Shonzo Hirota
MGI ID: MGI:3773048
Synonyms: KIT-Asp818Tyr
Gene: Kit  Location: Chr5:75574916-75656722 bp, + strand  Genetic Position: Chr5, 39.55 cM
Germline Transmission:  Earliest citation of germline transmission: J:130890
Parent Cell Line:  iTL1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsA floxed neo cassette and an exon 17 carrying a nucleotide substitution that results in an amino acid substitution of tyrosine for aspartic acid at position 818 (D818Y) was knocked into the open reading frame. The neo cassette was subsequently removed by germ-line, cre-mediated recombination. (J:130890)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kit Mutation:  109 strains or lines available
Original:  J:130890 Nakai N, et al., A mouse model of a human multiple GIST family with KIT-Asp820Tyr mutation generated by a knock-in strategy. J Pathol. 2008 Feb;214(3):302-11
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory