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Etv6tm3(NTRK3)Sho
Targeted Allele Detail
Summary
Symbol: Etv6tm3(NTRK3)Sho
Name: ets variant 6; targeted mutation 3, Stuart H Orkin
MGI ID: MGI:3772780
Gene: Etv6  Location: Chr6:134012663-134247121 bp, + strand  Genetic Position: Chr6, 64.58 cM, cytoband G2
Alliance: Etv6tm3(NTRK3)Sho page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:130323
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, No functional change)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neo and stopper cassette along with the coding region of human NTRK3 from exon 6 with a polyadenylation signal was knocked into and replaced exon 6 and 7. The allele produces a fusion protein of the amino acids coded by the first 5 exons and protein tyrosine kinase domain of NTRK3. Expression of the fusion protein only occurs when the stopper cassette is removed by cre-mediated recombination. (J:130323)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Tumor Data
List all tumor models in MMHCdb carrying Etv6tm3(NTRK3)Sho
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Etv6 Mutation:  142 strains or lines available
Notes
This fusion product recapitulates the t(12;15)(p13;25q) translocation characteristic of human secretory breast carcinomas.
References
Original:  J:130323 Li Z, et al., ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex. Cancer Cell. 2007 Dec;12(6):542-58
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory