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Tg(Prnp-TBP*)105Xjl
Transgene Detail
Summary
Symbol: Tg(Prnp-TBP*)105Xjl
Name: transgene insertion 105, Xiao-Jiang Li
MGI ID: MGI:3772700
Synonyms: TBP-105Q
Transgene: Tg(Prnp-TBP*)105Xjl  Location: unknown  
Alliance: Tg(Prnp-TBP*)105Xjl page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Prnp-TBP*)105Xjl expresses 1 gene
 
Mutation detailsA transgenic construct containing the human TATA box binding protein, TBP, containing a 105 polyQ repeat expansion, under the control of the mouse prion protein promoter was injected into fertilized FVB/N mouse eggs. Founder line TBP-105Q was established. The 105 polyQ-expansion was detected in the cerebral cortex and cerebellum by Western blot analysis. (J:130775)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:130775 Friedman MJ, et al., Polyglutamine domain modulates the TBP-TFIIB interaction: implications for its normal function and neurodegeneration. Nat Neurosci. 2007 Dec;10(12):1519-28
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory