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Bcat2tm1.2Clyn
Targeted Allele Detail
Nomenclature
Symbol: Bcat2tm1.2Clyn
Name: branched chain aminotransferase 2, mitochondrial; targeted mutation 1.2, Christopher Lynch
MGI ID: MGI:3772355
Synonyms: BCATm-, BCATm KO
Gene: Bcat2  Location: Chr7:45570153-45589711 bp, + strand  Genetic Position: Chr7, 29.36 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:129967
Parent Cell Line:  XSV1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsCre-mediated recombination removed exons 4 - 6, including multiple key active site residues. Protein expression is absent from the skeletal muscle, kidney, heart, brain, pancreas, and adipose tissue in homozygous mice. (J:129967)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bcat2 Mutation:  185 strains or lines available
References
Original:  J:129967 She P, et al., Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle. Cell Metab. 2007 Sep;6(3):181-94
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory