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Olr1tm1Meht
Targeted Allele Detail
Nomenclature
Symbol: Olr1tm1Meht
Name: oxidized low density lipoprotein (lectin-like) receptor 1; targeted mutation 1, Jawahra L Mehta
MGI ID: MGI:3772336
Synonyms: LOX-1-, LOX-1-KO
Gene: Olr1  Location: Chr6:129485244-129507165 bp, - strand  Genetic Position: Chr6, 63.35 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:130794
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 6, 7 and part of 8 were replaced with a neo cassette. The lack of transcript was confirmed by RT-PCR analysis and immunostaining of aortic tissues. (J:130794)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Olr1 Mutation:  23 strains or lines available
References
Original:  J:130794 Mehta JL, et al., Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet. Circ Res. 2007 Jun 8;100(11):1634-42
All:  24 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory