Mmp16^tm1Khol
Targeted Allele Detail

Summary

• Symbol: Mmp16^tm1Khol
• Name: matrix metallopeptidase 16; targeted mutation 1, Kenn Holmbeck
• MGI ID: MGI:3771975
• Synonyms: mt3-mmp^-
• Gene: Mmp16 Location: Chr4:17853072-18117479 bp, + strand Genetic Position: Chr4, 7.08 cM
• Alliance: Mmp16^tm1Khol page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130212
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 1 was replaced with a neo cassette. The absence of transcript was confirmed by RT-PCR. (J:130212)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mmp16 Mutation: 43 strains or lines available

References

• Original: J:130212 Shi J, et al., Membrane-type MMPs enable extracellular matrix permissiveness and mesenchymal cell proliferation during embryogenesis. Dev Biol. 2008 Jan 1;313(1):196-209
• All: 2 reference(s)