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Dmbt1tm1Janm
Targeted Allele Detail
Nomenclature
Symbol: Dmbt1tm1Janm
Name: deleted in malignant brain tumors 1; targeted mutation 1, Jan Mollenhauer
MGI ID: MGI:3771872
Synonyms: Dmbt1-
Gene: Dmbt1  Location: Chr7:131032053-131121630 bp, + strand  Genetic Position: Chr7, 73.2 cM, cytoband F4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:130258
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA loxP site was inserted about 1kb upstream of exon 1 and a loxP-flanked neo selection cassette was inserted into intron 1. Transient transfection of Cre-recombinase deleted the genomic sequence encoding part of the promoter, the upstream untranslated region of the gene, exon 1 which contains the ATG site and part of the coding sequence for the signal peptide, and a portion of intron 1. A single loxP site remained in place of the deleted gene sequence. Gene inactivation was confirmed by Northern and Western analysis of small intestine tissue. (J:130258)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dmbt1 Mutation:  46 strains or lines available
References
Original:  J:130258 Renner M, et al., DMBT1 confers mucosal protection in vivo and a deletion variant is associated with Crohn's disease. Gastroenterology. 2007 Nov;133(5):1499-509
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/11/2017
MGI 6.10
The Jackson Laboratory