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Ptf1atm2(cre/ESR1)Cvw
Targeted Allele Detail
Nomenclature
Symbol: Ptf1atm2(cre/ESR1)Cvw
Name: pancreas specific transcription factor, 1a; targeted mutation 2, Christopher VE Wright
MGI ID: MGI:3771322
Synonyms: Ptf1aCre-ERTM
Gene: Ptf1a  Location: Chr2:19445663-19447501 bp, + strand  Genetic Position: Chr2, 13.37 cM, cytoband A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:180310
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsRMCE using Ptf1atm1Mgn inserted a cre and mouse Esr1 (CreERTM) replacing exon 1 and 2 and a hygromycin resistance cassette downstream of exon 2. Flp-mediated recombination removed the FRT-flanked hygro cassette. (J:180310, J:194063)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Ptf1a     Summary of all recombinase alleles driven by Ptf1a. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ptf1a Mutation:  18 strains or lines available
References
Original:  J:180310 Kopinke D, et al., Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas. Dev Biol. 2012 Feb 1;362(1):57-64
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory