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Targeted Allele Detail
Symbol: Hpgdtm1Ljm
Name: hydroxyprostaglandin dehydrogenase 15 (NAD); targeted mutation 1, Louis J Muglia
MGI ID: MGI:3771208
Synonyms: HpgdH
Gene: Hpgd  Location: Chr8:56294585-56321043 bp, + strand  Genetic Position: Chr8, 29.7 cM, cytoband B3.2
Germline Transmission:  Earliest citation of germline transmission: J:130001
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Hypomorph)
Mutation:    Insertion
Mutation detailsIn the process of creating a loxP-flanked allele, a tandem duplication of exon 1 and 2 with an frt-flanked neo cassete and a 5' loxP site inserted into intron 2 was knocked into the gene. The authors state that this allele is hypomorphic. Northern blot analysis confirmed reduced transcript levels in the lungs and the absence of transcript in the liver and placenta of E17.5 embryos. Enzymatic assays confirmed decreased activity in the adult lungs, liver and E15.5 placenta. (J:130001)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hpgd Mutation:  11 strains or lines available
Original:  J:130001 Roizen JD, et al., Preterm Birth without Progesterone Withdrawal in 15-Hydroxyprostaglandin Dehydrogenase Hypomorphic Mice. Mol Endocrinol. 2008 Jan;22(1):105-12
All:  1 reference(s)

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MGI 6.12
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