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Tg(HIV)26Aln
Transgene Detail
Nomenclature
Symbol: Tg(HIV)26Aln
Name: transgene insertion 26, Abner Louis Notkins
MGI ID: MGI:3771187
Synonyms: T26, Tg26, Tg26HIV, TgFVB, TgN(pNL43d14), TgN(pNL43d14)26Lom 26
Transgene: Tg(HIV)26Aln  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsA noninfectious provirus transgene was engineered from an infectious clone of an integrated HIV virus (pNL4-3) by deleting 3.1 kb of sequence between the Sphl site at base position 1443 and the Ball site at position 4551 (Fig. 1A). The in-frame deletion of gag and pol sequences encompasses the coding sequences for p24, p15, protease, reverse transcriptase, and the amino-terminus of p34 endonuclease. This construct, designated pEVdl443, expressed HIV-1 envelope glycoproteins and Tat protein and encodes the regulatory gene products Nef and Rev, as well as Vpu, Vpr, Vif, and a pl7/p34 fusion gene product. In addition to transgenic line 26, lines 22c and 25 were also established. (J:90297)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:90297 Dickie P, et al., HIV-associated nephropathy in transgenic mice expressing HIV-1 genes. Virology. 1991 Nov;185(1):109-19
All:  48 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory