Wnk4^tm1Suc
Targeted Allele Detail

Summary

• Symbol: Wnk4^tm1Suc
• Name: WNK lysine deficient protein kinase 4; targeted mutation 1, Shinichi Uchida
• MGI ID: MGI:3771073
• Synonyms: Wnk4^D561A
• Gene: Wnk4 Location: Chr11:101151393-101168235 bp, + strand Genetic Position: Chr11, 64.51 cM
• Alliance: Wnk4^tm1Suc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:129716
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: A nucleotide substitution leading to the amino acid substitution of alanine for aspartic acid at position 561 (D561A) was knocked into exon 7 along with a floxed neo cassette that was subsequently removed by cre-mediated recombination. (J:129716)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Wnk4 Mutation: 56 strains or lines available

References

• Original: J:129716 Yang SS, et al., Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model. Cell Metab. 2007 May;5(5):331-44
• All: 11 reference(s)