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Tg(Ins2-rtTA)2Efr
Transgene Detail
Nomenclature
Symbol: Tg(Ins2-rtTA)2Efr
Name: transgene insertion 2, Shimon Efrat
MGI ID: MGI:3770667
Synonyms: Ins-rtTA, RIP7-rtTA, RiprtTA
Transgene: Tg(Ins2-rtTA)2Efr  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x CBA)F2
Transgene
description
Transgene Type:    Transgenic (Transactivator)
Mutation:    Insertion
 
Mutation detailsA transgenic construct containing 9.5kb 5' regulatory sequence and first intron of the rat insulin 2 gene (RIP7) controlling the reverse tetracycline transactivator (rtTA), as well as the polyadenylation site sequence of the RIP7 gene was injected into fertilized (C57BL/6 X CBA)F2 mouse eggs. Founder line 2 with 10 copies of the transgene was established. When mice are crossed to transgenic mice carrying reporter genes, transgene expression is detected only in pancreatic islet beta cells. (J:130049)
Phenotypes
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
References
Original:  J:130049 Milo-Landesman D, et al., Correction of hyperglycemia in diabetic mice transplanted with reversibly immortalized pancreatic beta cells controlled by the tet-on regulatory system. Cell Transplant. 2001;10(7):645-50
All:  28 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory