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Transgene Detail
Symbol: Tg(IGFBP1)2Miel
Name: transgene insertion 2, John Miell
MGI ID: MGI:3769998
Synonyms: c1:2-2, hIGFBP-1 (line c1:2-2)
Transgene: Tg(IGFBP1)2Miel  Location: unknown  
Placental morphology and histology indicates differences in trophoblast invasion and differentiation in Tg(IGFBP1)2Miel/0 mice

Show the 1 phenotype image(s) involving this allele.

Strain of Origin:  C57BL and CBA
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(IGFBP1)2Miel expresses 1 gene
Mutation detailsThe hIGFBP-1 transgene (isolated from a human cosmid clone) contains the entire structural IGFBP1 gene and all the cis acting sequences necessary to direct appropriate tissue-specific and regulated gene expression. Founder mice (line c1:2-2) were bred to CBA/Ca and the transgene copy number was found to be between 8 and 20. (J:128964)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:128964 Crossey PA, et al., Dysregulation of the insulin/IGF binding protein-1 axis in transgenic mice is associated with hyperinsulinemia and glucose intolerance. Diabetes. 2000 Mar;49(3):457-65
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory