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Transgenic Allele Detail
Symbol: Del(7Herc2-Mkrn3)13FRdni
Name: deletion, Chr 7, R D Nicholls13F; deletion, Chr 7, R D Nicholls 13F
MGI ID: MGI:3769770
Synonyms: Del13FRdni, TgPWS/AS(del)
Gene: Del(7Herc2-Mkrn3)13FRdni  Location: Chr7:56050155-62420139 bp  Genetic Position: Chr7, Syntenic
Strain of Origin:  C57BL/6 x SJL
Transgene Type:    Transgenic
Mutations:    Insertion, Intergenic deletion
  Del(7Herc2-Mkrn3)13FRdni involves 285 genes/genome features (Herc2, Gm19187, Oca2 ...) View all
Mutation detailsTransgene insertion of Tg(Igh-Lmp2a)13FRdni (MGI:3769767) resulted in a 5Mb deletion covering the entire Prader-Willi syndrom homology region. (J:56614, J:103338)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Del(7Herc2-Mkrn3)13FRdni Mutation:  1 strain or line available
This deletion was generated in mice carrying Tg(Igh-Lmp2a)13FRdni. 9 lines were created with the eight others exhibiting lymphocyte cell lineage defects. Line 13F results in a deletion in chromosome 7 from Mkrn3 to Herc2 (Mkrn3, Ndn, Snurf/Snrpn, Ube3a, and Herc2 are deleted).

Original:  J:56614 Gabriel JM, et al., A transgene insertion creating a heritable chromosome deletion mouse model of Prader-Willi and angelman syndromes. Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9258-63
All:  7 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory