Gt(ROSA)26Sor^tm1(Wnt4)Bhr
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^tm1(Wnt4)Bhr
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Richard R Behringer
• MGI ID: MGI:3769474
• Synonyms: R26^floxneoWnt4
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^tm1(Wnt4)Bhr page

Growth defects in Gt(ROSA)26Sor^tm1(Wnt4)Bhr/Gt(ROSA)26Sor⁺ Tg(Col2a1-cre)1Bhr/0 mice

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:129327
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^tm1(Wnt4)Bhr expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Wnt4 (MGI:98957)

• Mutation details: Murine Wnt4 coding sequence was inserted into the locus downstream of a floxed neomycin selection cassette. The neo cassette has five polyadenylation sequences preventing transcription of the Wnt4 gene. Upon cre expression, the neomycin cassette is removed and Wnt4 is expressed. (J:129327)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 942 strains or lines available

References

• Original: J:129327 Lee HH, et al., Conditional expression of Wnt4 during chondrogenesis leads to dwarfism in mice. PLoS One. 2007;2(5):e450
• All: 1 reference(s)