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Targeted Allele Detail
Symbol: Trdntm1.1Cfp
Name: triadin; targeted mutation 1.1, Claudio F Perez
MGI ID: MGI:3769415
Synonyms: Trdn-
Gene: Trdn  Location: Chr10:33083483-33476709 bp, + strand  Genetic Position: Chr10, 18.37 cM, cytoband B1
Germline Transmission:  Earliest citation of germline transmission: J:128951
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsA floxed neo cassette was inserted into the promoter region and an additional loxP site was inserted downstream of exon 1. Exon 1 and neo cassette were removed by germline cre-mediated recombination. The absence of protein product was confirmed by western blot on fast and slow twitch muscle extracts. (J:128951)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trdn Mutation:  33 strains or lines available
Original:  J:128951 Shen X, et al., Triadins modulate intracellular Ca2+ homeostasis but are not essential for excitation-contraction coupling in skeletal muscle. J Biol Chem. 2007 Dec 28;282(52):37864-74
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
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