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Targeted Allele Detail
Symbol: Zmiz1tm1Zsu
Name: zinc finger, MIZ-type containing 1; targeted mutation 1, Zijie Sun
MGI ID: MGI:3769389
Synonyms: Zimp10-
Gene: Zmiz1  Location: Chr14:25459185-25666743 bp, + strand  Genetic Position: Chr14, 15.03 cM
Germline Transmission:  Earliest citation of germline transmission: J:128915
Parent Cell Line:  iTL1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 2.7 kb fragment including exons 8 - 10 (amino acids 149 - 314) was replaced with a pgk-neo cassette. This deletion resulted in a frameshift producing a missense mutation in the remaining transcript. Western blot analysis of homozygous embryos confirmed the absence of full-length protein. (J:128915)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Zmiz1 Mutation:  27 strains or lines available
Original:  J:128915 Beliakoff J, et al., The PIAS-like protein Zimp10 is essential for embryonic viability and proper vascular development. Mol Cell Biol. 2008 Jan;28(1):282-92
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory