Tg(Lck-Jak3)2Ljb
Transgene Detail

Summary

• Symbol: Tg(Lck-Jak3)2Ljb
• Name: transgene insertion 2, Leslie J Berg
• MGI ID: MGI:3769343
• Synonyms: Tg^thy
• Transgene: Tg(Lck-Jak3)2Ljb Location: unknown
• Alliance: Tg(Lck-Jak3)2Ljb page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Lck-Jak3)2Ljb expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Jak3 (MGI:99928)

• Mutation details: This transgene expresses a murine Jak3 cDNA under the control of the Lck proximal promoter. Transgene expression is initially detected in the thymocytes and peripheral T cells but is gradually lost in peripheral T cells. (J:128694)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:128694 Thomis DC, et al., Peripheral expression of Jak3 is required to maintain T lymphocyte function. J Exp Med. 1997 Jan 20;185(2):197-206
• All: 2 reference(s)