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Targeted Allele Detail
Symbol: Sirt4tm1Fwa
Name: sirtuin 4; targeted mutation 1, Frederick W Alt
MGI ID: MGI:3769237
Synonyms: Sirt4tm1Lgu
Gene: Sirt4  Location: Chr5:115478010-115484725 bp, - strand  Genetic Position: Chr5, 56.1 cM, cytoband F
Germline Transmission:  Earliest citation of germline transmission: J:129427
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 1 through 3 were replaced with a lacZ gene inserted in-frame after the first 21 bp of exon 1. The absence of protein product was confirmed by western blot analysis on brain, pancreas and liver extracts. (J:129427)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sirt4 Mutation:  23 strains or lines available
Original:  J:129427 Haigis MC, et al., SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell. 2006 Sep 8;126(5):941-54
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.06
The Jackson Laboratory