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Sirt5tm1Fwa
Targeted Allele Detail
Nomenclature
Symbol: Sirt5tm1Fwa
Name: sirtuin 5; targeted mutation 1, Frederick W Alt
MGI ID: MGI:3769236
Gene: Sirt5  Location: Chr13:43370710-43395202 bp, + strand  Genetic Position: Chr13, 21.6 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:129009
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2 through 5 were replaced with a lacZ gene inserted in frame after the 23rd base pair of exon 2. The absence of protein product was confirmed by western blot analysis on liver extracts. (J:129009)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sirt5 Mutation:  15 strains or lines available
References
Original:  J:129009 Lombard DB, et al., Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol. 2007 Dec;27(24):8807-14
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory