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Targeted Allele Detail
Symbol: Sirt3tm1.1Fwa
Name: sirtuin 3; targeted mutation 1.1, Frederick W Alt
MGI ID: MGI:3769234
Synonyms: Sirt3-
Gene: Sirt3  Location: Chr7:140863670-140882309 bp, - strand  Genetic Position: Chr7, 86.07 cM, cytoband F4
Germline Transmission:  Earliest citation of germline transmission: J:129009
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsA floxed neo cassette was inserted into intron 3 and an additional loxP site was inserted upstream of exon 2. Cre-mediated recombination was used to remove the neo cassette, exon 2 and exon 3. The absence of protein product was confirmed by western blot analysis on liver and brain extracts. (J:129009)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sirt3 Mutation:  15 strains or lines available
Phenotypic Similarity to Human Syndrome: Metabolic Syndrome in homozygous mice (J:178653)

Original:  J:129009 Lombard DB, et al., Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol. 2007 Dec;27(24):8807-14
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.0
The Jackson Laboratory