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Map2k4tm1Ctr
Targeted Allele Detail
Summary
Symbol: Map2k4tm1Ctr
Name: mitogen-activated protein kinase kinase 4; targeted mutation 1, Cathy Tournier
MGI ID: MGI:3769117
Synonyms: mkk4fl, mkk4-flox
Gene: Map2k4  Location: Chr11:65579069-65679123 bp, - strand  Genetic Position: Chr11, 40.53 cM
Alliance: Map2k4tm1Ctr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:129038
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA floxed neo cassette was inserted downstream of exon 4 and an additional loxP site was inserted upstrem of exon 4. The floxed neo cassette was removed by cre-mediated recombination using a cre-expressing plasmid. (J:129038)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Map2k4tm1Ctr
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Map2k4 Mutation:  32 strains or lines available
References
Original:  J:129038 Wang X, et al., Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death. Mol Cell Biol. 2007 Nov;27(22):7935-46
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory