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Targeted Allele Detail
Symbol: Map2k4tm1Ctr
Name: mitogen-activated protein kinase kinase 4; targeted mutation 1, Cathy Tournier
MGI ID: MGI:3769117
Synonyms: mkk4fl, mkk4-flox
Gene: Map2k4  Location: Chr11:65688243-65788297 bp, - strand  Genetic Position: Chr11, 40.53 cM
Germline Transmission:  Earliest citation of germline transmission: J:129038
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA floxed neo cassette was inserted downstream of exon 4 and an additional loxP site was inserted upstrem of exon 4. The floxed neo cassette was removed by cre-mediated recombination using a cre-expressing plasmid. (J:129038)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Map2k4 Mutation:  23 strains or lines available
Original:  J:129038 Wang X, et al., Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death. Mol Cell Biol. 2007 Nov;27(22):7935-46
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory