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Tg(Tyr-NRAS*Q61K)1Bee
Transgene Detail
Nomenclature
Symbol: Tg(Tyr-NRAS*Q61K)1Bee
Name: transgene insertion 1, Friedrich Beemann
MGI ID: MGI:3768645
Synonyms: Tyr::N-RasQ61K
Transgene: Tg(Tyr-NRAS*Q61K)1Bee  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6J x DBA/2)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Tyr-NRAS*Q61K)1Bee expresses 1 gene
 
Mutation detailsThe tyrosinase promoter is used to drive the expression of human nras containing the amino acid sustitution lysine for a glutamine at position 61. Expression is directed towards melanocyte lineages. (J:98545)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:98545 Ackermann J, et al., Metastasizing melanoma formation caused by expression of activated N-RasQ61K on an INK4a-deficient background. Cancer Res. 2005 May 15;65(10):4005-11
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory