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Chn1tm1.1Abet
Targeted Allele Detail
Nomenclature
Symbol: Chn1tm1.1Abet
Name: chimerin 1; targeted mutation 1.1, Andrea Betz
MGI ID: MGI:3768535
Synonyms: alpha-chimaerin-
Gene: Chn1  Location: Chr2:73610660-73775346 bp, - strand  Genetic Position: Chr2, 43.78 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:128724
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed lacZ-IRES cassette with a splice acceptor and a frt-flanked neo cassette were inserted between exon 8 and 9 and an additional loxP site was inserted upstream of exon 8. Cre-mediated recombination was used to remove exon 8 and the lacZ cassette. The absence of alpha1-chimaerin and alpha2-chimaerin was confirmed by western blot analysis on total brain extracts. (J:128724)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chn1 Mutation:  23 strains or lines available
References
Original:  J:128724 Wegmeyer H, et al., EphA4-dependent axon guidance is mediated by the RacGAP alpha2-chimaerin. Neuron. 2007 Sep 6;55(5):756-67
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/14/2017
MGI 6.08
The Jackson Laboratory