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Tg(Prnp-MAPT*P301S)PS19Vle
Transgene Detail
Nomenclature
Symbol: Tg(Prnp-MAPT*P301S)PS19Vle
Name: transgene insertion PS19, Virginia M Y Lee
MGI ID: MGI:3768407
Synonyms: P301S tau (line PS19), PS19 Tg
Transgene: Tg(Prnp-MAPT*P301S)PS19Vle  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x C3H)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Prnp-MAPT*P301S)PS19Vle expresses 1 gene
 
Mutation detailsThe transgene construct contains the P301S mutant human microtubule-associated protein tau, MAPT, under the direction of the mouse prion protein, Prnp, promoter. The expression of the mutant human MAPT is 5-fold higher than the expression of the endogenous mouse Mapt protein. (J:119741)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
References
Original:  J:119741 Yoshiyama Y, et al., Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron. 2007 Feb 1;53(3):337-51
All:  24 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory