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Targeted Allele Detail
Symbol: Bco1tm1Dnp
Name: beta-carotene oxygenase 1; targeted mutation 1, Adrian Wyss
MGI ID: MGI:3767552
Synonyms: CMO1-, CMO1tm1dnp
Gene: Bco1  Location: Chr8:117095854-117133720 bp, + strand  Genetic Position: Chr8, 63.61 cM, cytoband E1
Germline Transmission:  Earliest citation of germline transmission: J:128383
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAn IRES-lacZ gene and floxed neo cassette replaced an 8.8 kb fragment including half of exon 2 and exon 3. Immunoblot analysis of homozygous livers confirmed absence of protein expression. (J:128383)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 29 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bco1 Mutation:  21 strains or lines available
Original:  J:128383 Hessel S, et al., CMO1 deficiency abolishes vitamin A production from beta-carotene and alters lipid metabolism in mice. J Biol Chem. 2007 Nov 16;282(46):33553-61
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory