Tg(Ascl1-cre/Esr1*)1Jejo
Transgene Detail

Summary

• Symbol: Tg(Ascl1-cre/Esr1*)1Jejo
• Name: transgene insertion 1, Jane Johnson
• MGI ID: MGI:3767428
• Synonyms: Ascl1-CreER^TM, line B2C-6, Mash1BAC-CreER, Tg(Ascl1-cre/ESR1)1Jejo
• Transgene: Tg(Ascl1-cre/Esr1*)1Jejo Location: unknown
• Alliance: Tg(Ascl1-cre/Esr1*)1Jejo page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA)F1

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Ascl1-cre/Esr1*)1Jejo expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Ascl1

• Mutation details: The transgene contains a BAC in which the Ascl1 open reading frame is replaced with a cre-estrogen response element fusion. Expression of cre, detected following a cross to a reporter strain, is restricted to the midbrain at E10.5, the developing sympathetic neurons at E10.5 and E11.5, the enteric nervous system, diencephalon and hindbrain at E11.5, and the dorsal neural tube at E12.5 reflecting the endogenous expression pattern of the gene. Two lines were established (B2C-6 and B2C-8). B2C-6 was analyzed in more detail and is represented by line 1 here. (J:117032)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ascl1 (species not specified) Summary of all recombinase alleles driven by Ascl1. Comparative matrix view of recombinase activities

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:117032 Battiste J, et al., Ascl1 defines sequentially generated lineage-restricted neuronal and oligodendrocyte precursor cells in the spinal cord. Development. 2007 Jan;134(2):285-93
• All: 18 reference(s)