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Seletm2Alb
Targeted Allele Detail
Nomenclature
Symbol: Seletm2Alb
Name: selectin, endothelial cell; targeted mutation 2, Arthur L Beaudet
MGI ID: MGI:3767067
Synonyms: E/P-
Gene: Sele  Location: Chr1:164048234-164057677 bp, + strand  Genetic Position: Chr1, 71.35 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:33135
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsSequence extending from within exon 4 through a portion of 6 was replaced by an hprt minigene inserted by homologous recombination. This plasmid construct was electroporated into AB2.1 ES cells carrying a P-selectin (Selp) mutation (J:24239) and clones with the two mutations in cis were used to produce Sele/Selp double mutants. (J:33135)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sele Mutation:  25 strains or lines available
References
Original:  J:33135 Bullard DC, et al., Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice. J Exp Med. 1996 May 1;183(5):2329-36
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory