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Targeted Allele Detail
Symbol: Del(11Mpo-Chad)18Brd
Name: deletion, Chr 11, Bradley 18; deletion, Chr 11, Allan Bradley 18
MGI ID: MGI:3766573
Synonyms: Del18Brd, Df(11)18
Gene: Del(11Mpo-Chad)18Brd  Location: Chr11:87793581-94569127 bp  Genetic Position: Chr11, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:109163
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Null/knockout)
Mutation:    Intergenic deletion
  Del(11Mpo-Chad)18Brd involves 100 genes/genome features (Gm11499, Mpo, Gm11505 ...) View all
Mutation detailsA loxP site was targeted into the Mpo gene. A second loxP site was targeted in trans into the Chad gene. Transient expression of Cre recombinase in ES cells resulted in recombination between loxP sites on opposite chromosomes, deleting the 6.9 Mb region from Mpo to Chad. (J:109163)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Del(11Mpo-Chad)18Brd Mutation:  0 strains or lines available
Original:  J:109163 Yu YE, et al., A deficiency in the region homologous to human 17q21.33-q23.2 causes heart defects in mice. Genetics. 2006 May;173(1):297-307
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.04
The Jackson Laboratory