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Tg(Tnf)6074Gkl
Transgene Detail
Nomenclature
Symbol: Tg(Tnf)6074Gkl
Name: transgene insertion 6074, George Kollias
MGI ID: MGI:3766101
Synonyms: Tg6074
Transgene: Tg(Tnf)6074Gkl  Location: unknown  
Transgene
origin
Strain of Origin:  (CBA x C57BL/6)F2
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Tnf)6074Gkl expresses 1 gene
 
Mutation detailsThese mice express a construct which contains the promoter and entire coding region of the murine TNF-alpha gene. A 0.77-kb EcoRI-Pst I/Sal I fragment, containing the 3'-untranslated region and polyadenylylation site of the human beta-globin gene was ligated to the 3' end of the murine gene. The transgene is expressed specifically in neuron cell bodies of the CNS and is detected in all areas tested including the cerebral cortex, cerebellum, diencephalon, brain stem, and spinal cord. Expression is not detected in astrocyte cultures, activated peritoneal macrophages or activated splenocytes. Expression is first detectable at low levels in P6 mice and increases greatly in intensity until P15 after which expression remains at high levels. (J:111326)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
model for multiple sclerosis (J:89603)

References
Original:  J:111326 Probert L, et al., Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha. Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):11294-8
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory