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Transgenic Allele Detail
Symbol: Timo
Name: transgenic insertional mutants with obesity
MGI ID: MGI:3766100
Gene: Timo  Location: unknown  Genetic Position: Chr2, Syntenic
Strain of Origin:  (C57BL/6J x CBA/CaJ)F1
Transgene Type:    Transgenic
Mutation:    Insertion
Mutation detailsA transgene containing a mouse Flk1 promotor, mouse Rage cDNA, and SV40 polyA signal inserted between 108,618,208 and 108,618,659 bp in Chromosome 2, approximately 857 kb upstream of the transcription start site of Bdnf. No transgene expression is seen. Bdnf mRNA and protein expression levels are reduced in the hippocampus and hypothalmus. Serum BDNF levels are about 30% of non-transgenic controls. Reduction in expression varies with the hypothalamus most severely affected followed by the hippocampus, but no significant reduction in expression in the lung. Several conserved elements are located in the insertion region and functional analysis indicated that some of these enhance Bdnf expression. (J:127183)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Timo Mutation:  0 strains or lines available
Original:  J:127183 Sha H, et al., Disruption of a novel regulatory locus results in decreased Bdnf expression, obesity, and type 2 diabetes in mice. Physiol Genomics. 2007 Oct 22;31(2):252-63
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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