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Ltbp1tm1Veto
Targeted Allele Detail
Nomenclature
Symbol: Ltbp1tm1Veto
Name: latent transforming growth factor beta binding protein 1; targeted mutation 1, Vesna Todorovic
MGI ID: MGI:3765966
Synonyms: Ltbp1L-
Gene: Ltbp1  Location: Chr17:75005568-75392512 bp, + strand  Genetic Position: Chr17, 46.24 cM, cytoband E3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:128012
Parent Cell Line:  F1H4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NTac)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details457 bp of the 3' portion of exon 1 and 209 bp of the downstream exon were deleted and replaced with a lacZ gene and neo cassette using Velocigene technology. The neo cassette was removed by cre-mediated recombination. The absence of protein was confirmed by western blot analysis on protein extracts from E14.5 hearts. (J:128012)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 54 assay results
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ltbp1 Mutation:  7 strains or lines available
Notes
Ltbp1tm1Veto and Ltbp1tm2Veto mice exhibit identical defects.
References
Original:  J:128012 Todorovic V, et al., Long form of latent TGF-beta binding protein 1 (Ltbp1L) is essential for cardiac outflow tract septation and remodeling. Development. 2007 Oct;134(20):3723-32
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory