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Vasptm1Ref
Targeted Allele Detail
Nomenclature
Symbol: Vasptm1Ref
Name: vasodilator-stimulated phosphoprotein; targeted mutation 1, Reinhard Fassler
MGI ID: MGI:3764987
Synonyms: vv
Gene: Vasp  Location: Chr7:19256929-19271817 bp, - strand  Genetic Position: Chr7, 9.51 cM, cytoband A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:51905
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA promoterless lacZ-neo fusion gene lacking the first two amino acids and contianing the bovine growth horone poly A signal was inserted into exon 2 replacing exons 2 through 13. The lack of protein expresison was confirmed by western blot analysis on protein extracted from platelets, liver and the duodenum. (J:51905)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vasp Mutation:  25 strains or lines available
References
Original:  J:51905 Aszodi A, et al., The vasodilator-stimulated phosphoprotein (VASP) is involved in cGMP- and cAMP-mediated inhibition of agonist-induced platelet aggregation, but is dispensable for smooth muscle function. EMBO J. 1999 Jan 4;18(1):37-48
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/14/2017
MGI 6.08
The Jackson Laboratory