Evl^tm1Fbg
Targeted Allele Detail

Summary

• Symbol: Evl^tm1Fbg
• Name: Ena-vasodilator stimulated phosphoprotein; targeted mutation 1, Frank B Gertler
• MGI ID: MGI:3764986
• Synonyms: ee
• Gene: Evl Location: Chr12:108520979-108654775 bp, + strand Genetic Position: Chr12, 59.46 cM, cytoband F2
• Alliance: Evl^tm1Fbg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:127447
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3, encoding the EVH1 domain, were replaced with a neo cassette. The absence of protein product was confirmed by western blot analysis of protien extracted from adult brains. (J:127447)

Expression

In Mice Carrying this Mutation:

22 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Evl Mutation: 48 strains or lines available

References

• Original: J:127447 Kwiatkowski AV, et al., Ena/VASP Is Required for neuritogenesis in the developing cortex. Neuron. 2007 Nov 8;56(3):441-55
• All: 6 reference(s)