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Transgene Detail
Symbol: Tg(GUSB)4Sly
Name: transgene insertion 4, William S Sly
MGI ID: MGI:3764916
Synonyms: TgGUSB
Transgene: Tg(GUSB)4Sly  Location: unknown  
Lysosomal storage disease is evident in Gusbmps/Gusbmps mice and is rescued by Tg(GUSB)4Sly/Tg(GUSB)4Sly expression

Show the 1 phenotype image(s) involving this allele.

Strain of Origin:  C57BL/6J
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(GUSB)4Sly expresses 1 gene
Mutation detailsThe entire human beta-glucuronidase gene with 1.6kb of 5'-flanking sequence and 3.8kb of 3'-flanking sequence was microinjected into C57BL/6J zygotes. Founder line 4 was subsequently propagated. Mice that are homozygous for this transgene and the Gusbmps allele have approximately 20-fold higher beta-glucuronidase enzyme activity than wildtype controls. Distribution of human enzyme activity throughout various tissues mimics the endogenous mouse enzyme activity pattern. (J:21256)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Original:  J:21256 Kyle JW, et al., Correction of murine mucopolysaccharidosis VII by a human beta-glucuronidase transgene. Proc Natl Acad Sci U S A. 1990 May;87(10):3914-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
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