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Terttm1Sear
Targeted Allele Detail
Nomenclature
Symbol: Terttm1Sear
Name: telomerase reverse transcriptase; targeted mutation, Steven E Artandi
MGI ID: MGI:3764898
Synonyms: TERT-
Gene: Tert  Location: Chr13:73627001-73649041 bp, + strand  Genetic Position: Chr13, 40.12 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:127153
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Not Specified
 
Mutation detailsThe gene locus contains 15 exons. A linearized targeting vector containing a neomycin cassette in the reverse orientation and exons 3-8 was used. After targeting, the allele contained a neomycin cassette in the reverse orientation after the endogenous exon 8, with exons 3-8 repeated downstream of the neo cassette. Insertion caused gene inactivation as determined by semi-quantitative RT-PCR on embryonic fibroblasts, liver, and testes. (J:127153, J:150343)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tert Mutation:  4 strains or lines available
References
Original:  J:127153 Rajaraman S, et al., Telomere uncapping in progenitor cells with critical telomere shortening is coupled to S-phase progression in vivo. Proc Natl Acad Sci U S A. 2007 Nov 6;104(45):17747-52
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/17/2015
MGI 5.21
The Jackson Laboratory