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Tg(Cryaa-TAg)7488Lmgd
Transgene Detail
Nomenclature
Symbol: Tg(Cryaa-TAg)7488Lmgd
Name: transgene insertion 7488, Laboratory of Mammalian Genes and Development, Heiner Westphal
MGI ID: MGI:3764829
Synonyms: a-crys-Tag, alpha-crys-Tag
Transgene: Tg(Cryaa-TAg)7488Lmgd  Location: unknown  
Transgene
origin
Strain of Origin:  Not Applicable
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThe transgenic construct consists of 416 bp of the 5' flanking sequence from the murine alpha-A crystallin gene (Cryaa) fused to the coding sequence of the SV40 early region. Transgenic F0 animals generally died prematurely by 4 months of age so only one line, 7488, bearing 2 copies of the transgene, was propagated. Expression is lens-specific. Transgene expression is identified by white and opaque appearance of the eyes upon opening, instead of a normal transparent lens. (J:127709)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:127709 Mahon KA, et al., Oncogenesis of the lens in transgenic mice. Science. 1987 Mar 27;235(4796):1622-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory