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Cyp26b1tm1Ptk
Targeted Allele Detail
Summary
Symbol: Cyp26b1tm1Ptk
Name: cytochrome P450, family 26, subfamily b, polypeptide 1; targeted mutation 1, Martin Petkovich
MGI ID: MGI:3764691
Synonyms: Cyp26b1fl, L3
Gene: Cyp26b1  Location: Chr6:84548396-84570890 bp, - strand  Genetic Position: Chr6, 36.45 cM
Alliance: Cyp26b1tm1Ptk page
Loss of germ cells in adult Cyp26b1tm1Ptk/Cyp26b1tm1Ptk Plekha5Tg(AMH-cre)1Flor/0 animals

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:126705
Parent Cell Line:  H1 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA single loxP site was inserted 5' to exon 3 and a loxP flanked neomycin selection cassette was inserted 3' to exon 6. (J:126705)
Generation of the Cyp26b1tm1Ptk allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cyp26b1 Mutation:  35 strains or lines available
References
Original:  J:126705 MacLean G, et al., Apoptotic extinction of germ cells in testes of Cyp26b1 knockout mice. Endocrinology. 2007 Oct;148(10):4560-7
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory