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Tg(Ins2-CD86)12B70Flv
Transgene Detail
Nomenclature
Symbol: Tg(Ins2-CD86)12B70Flv
Name: transgene insertion 12B70, Richard Flavell
MGI ID: MGI:3764558
Synonyms: RIP-CD86
Transgene: Tg(Ins2-CD86)12B70Flv  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x CBA/Ca)F2
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Ins2-CD86)12B70Flv expresses 1 gene
 
Mutation detailsThe transgenic construct contains the human CD86 gene driven by the rat insulin 2 promoter (RIP). Transgenic protein expression is restricted to the Islets of Langerhans. (J:93555)
Inheritance:    Dominant
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:93555 Guerder S, et al., Autoimmunity without diabetes in transgenic mice expressing beta cell-specific CD86, but not CD80: parameters that trigger progression to diabetes. J Immunol. 1998 Sep 1;161(5):2128-40
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory