About   Help   FAQ
Targeted Allele Detail
Symbol: Adamts13tm1Myta
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13; targeted mutation 1, Toshiyuki Miyata
MGI ID: MGI:3763820
Synonyms: Adamts13-
Gene: Adamts13  Location: Chr2:26973416-27009628 bp, + strand  Genetic Position: Chr2, 19.14 cM
Germline Transmission:  Earliest citation of germline transmission: J:125786
Parent Cell Line:  CMTI-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe exons 3-6 that encode the catalytic domain of the protein were replaced with a neomycin resistance cassette. Elimination of gene expression in homozygotes was confirmed by quantitative RT PCR on liver RNA and by the lack of enzymatic activity of the gene product in plasma. (J:125786)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adamts13 Mutation:  45 strains or lines available
ES cell line = "R-CMTI-1A" (J:125786)
Original:  J:125786 Banno F, et al., Complete deficiency in ADAMTS13 is prothrombotic, but it alone is not sufficient to cause thrombotic thrombocytopenic purpura. Blood. 2006 Apr 15;107(8):3161-6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.12
The Jackson Laboratory