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Targeted Allele Detail
Symbol: Flt3tm1Dgg
Name: FMS-like tyrosine kinase 3; targeted mutation 1, D Gilliland
MGI ID: MGI:3763385
Synonyms: Flt3ITD, FLT3/ITD
Gene: Flt3  Location: Chr5:147330741-147400489 bp, - strand  Genetic Position: Chr5, 86.88 cM, cytoband G3
Germline Transmission:  Earliest citation of germline transmission: J:126003
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Humanized sequence)
Mutation:    Insertion
Mutation detailsThe human W51 mutation which causes the duplication of amino acid 596 to 602 (R-E-Y-E-Y-D-L) was inserted inframe into exon 14. A floxed neomycin selection cassette was inserted in intron 15 as well. DNA sequencing was performed to confirm the duplication in exon 14. (J:126003)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Flt3 Mutation:  6 strains or lines available
Original:  J:126003 Lee BH, et al., FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia. Cancer Cell. 2007 Oct;12(4):367-80
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.0
The Jackson Laboratory