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Mmp14sabe
Spontaneous Allele Detail
Nomenclature
Symbol: Mmp14sabe
Name: matrix metallopeptidase 14 (membrane-inserted); small and bugged-eyed
MGI ID: MGI:3763359
Gene: Mmp14  Location: Chr14:54431598-54442456 bp, + strand  Genetic Position: Chr14, 27.79 cM
Mmp14sabe/Mmp14sabe mouse (right) is small and short-nosed

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation detailsA C to T transition in Chromosome 14 bapse pair 54,436,154 (GRCm38) is predicted to cause a p.R92C mutation directly adjacent to a critical cysteine in the cysteine switch regulatory domain. (J:127164, J:223062)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mmp14 Mutation:  11 strains or lines available
References
Original:  J:127164 Curtain MM, et al., A possible new mutation to Mmp 14. MGI Direct Data Submission. 2007;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/07/2020
MGI 6.15
The Jackson Laboratory