Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 9, TaconicArtemis
• MGI ID: MGI:3763211
• Synonyms: CreER^T2, Ert2-Cre, Gt(ROSA)26Sor^{tm1(cre/ESR1)Arte}, Gt(ROSA)26Sor^{tm9(Cre/ESR1)Arte}CreER^T2, RCE, Rosa26CreER^T2, rosa26(SA-CreERT2)ARTE, Rosa(CreER⁺), rosa(CreER^T2), rosa(SAcreER^T2)
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126518
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gt(ROSA)26Sor (MGI:104735)

• Mutation details: A fusion protein consisting of cre recombinase and the mutated ligand binding domain of the human estrogen receptor (ERT2) was inserted into intron 1. The estrogen receptor contains 3 mutations (G400V, M543A, L544A) that increase sensitivity to tamoxifen. (J:126518)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gt(ROSA)26Sor (mouse) Summary of all recombinase alleles driven by Gt(ROSA)26Sor. Alliance mouse Gt(ROSA)26Sor gene page

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 942 strains or lines available

References

• Original: J:126518 Seibler J, et al., Rapid generation of inducible mouse mutants. Nucleic Acids Res. 2003 Feb 15;31(4):e12
• All: 202 reference(s)