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Grk2tm1.1Gwd
Targeted Allele Detail
Nomenclature
Symbol: Grk2tm1.1Gwd
Name: G protein-coupled receptor kinase 2; targeted mutation 1.1, Gerald W Dorn II
MGI ID: MGI:3763201
Synonyms: GRK2-
Gene: Grk2  Location: Chr19:4286001-4306222 bp, - strand  Genetic Position: Chr19, 3.98 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:126501
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExons 3 through 6 were removed by cre-mediated recombination following a cross Tg(EIIa-cre)C5379Lmgd mice. The absence of protein product was confirmed by western blot analsysis on protein extracts from whole E9.5 embryos. (J:126501)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grk2 Mutation:  24 strains or lines available
References
Original:  J:126501 Matkovich SJ, et al., Cardiac-specific ablation of G-protein receptor kinase 2 redefines its roles in heart development and beta-adrenergic signaling. Circ Res. 2006 Oct 27;99(9):996-1003
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/08/2017
MGI 6.10
The Jackson Laboratory