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Targeted Allele Detail
Symbol: Grk2tm1Gwd
Name: G protein-coupled receptor kinase 2; targeted mutation 1, Gerald W Dorn II
MGI ID: MGI:3763199
Synonyms: GRK2f
Gene: Grk2  Location: Chr19:4286001-4306222 bp, - strand  Genetic Position: Chr19, 3.98 cM
Germline Transmission:  Earliest citation of germline transmission: J:126501
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsExons 3 through 6 were flanked by loxP sites and a neo cassette flanked by frt sites was inserted 5' of exon 3. The neo cassette was removed by Flp-mediated recombination following a cross to Gt(ROSA)26Sortm1(FLP1)Dym mice. Southern blot analysis was performed to confirm the insertions. (J:126501)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Grk2 Mutation:  27 strains or lines available
Original:  J:126501 Matkovich SJ, et al., Cardiac-specific ablation of G-protein receptor kinase 2 redefines its roles in heart development and beta-adrenergic signaling. Circ Res. 2006 Oct 27;99(9):996-1003
All:  24 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory