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Targeted Allele Detail
Symbol: Lgr4tm1.2Knis
Name: leucine-rich repeat-containing G protein-coupled receptor 4; targeted mutation 1.2, Katsuhiko Nishimori
MGI ID: MGI:3762641
Gene: Lgr4  Location: Chr2:109917647-110014257 bp, + strand  Genetic Position: Chr2, 56.65 cM
Germline Transmission:  Earliest citation of germline transmission: J:127019
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsCre mediated recombination removed an Frt-flanked neo cassette and the part of exon 18 which codes for the transmembrane and signal-transducing domains. Immunostaining confirms the absence of expression in the protruding tips of the eyelids and in epithelial cells of the cornea. (J:126813, J:127019)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 15 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lgr4 Mutation:  76 strains or lines available
Original:  J:127019 Kato S, et al., Leucine-rich repeat-containing G protein-coupled receptor-4 (LGR4, Gpr48) is essential for renal development in mice. Nephron Exp Nephrol. 2006;104(2):e63-75
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory