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St8sia4tm1.1Mifu
Targeted Allele Detail
Nomenclature
Symbol: St8sia4tm1.1Mifu
Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4; targeted mutation 1.1, Minoru Fukuda
MGI ID: MGI:3762640
Synonyms: ST8IV-
Gene: St8sia4  Location: Chr1:95587682-95667571 bp, - strand  Genetic Position: Chr1, 47.76 cM, cytoband D
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:126687
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA floxed neo cassette was inserted into the 5' untranslated region and an additional loxP site was inserted downstream of exon 1. Cre-mediated recombination by transient expression of cre deleted the exon 1. which contains the initiation methionine and a transmembrane domain. Without the signal peptide and the transmembrane domain no functional protein is made. The lack of transcript was confirmed by RT-PCR. (J:126687)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any St8sia4 Mutation:  12 strains or lines available
References
Original:  J:126687 Angata K, et al., Polysialic acid-directed migration and differentiation of neural precursors are essential for mouse brain development. Mol Cell Biol. 2007 Oct;27(19):6659-68
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory