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Rspo2tm1Nuv
Targeted Allele Detail
Summary
Symbol: Rspo2tm1Nuv
Name: R-spondin 2; targeted mutation 1, Walter D Funk
MGI ID: MGI:3762378
Synonyms: Rspo2-LacZ
Gene: Rspo2  Location: Chr15:42884190-43034222 bp, - strand  Genetic Position: Chr15, 16.73 cM
Alliance: Rspo2tm1Nuv page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:126341
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 308 bp section spanning exon 3 (containing the first half of the cysteine-rich domain) is replaced with an IRES-lacZ-PGKneo cassette. RNA expression analysis fails to detect any transcript in the brains of P1 homozygous mice. LacZ expression recapitulates endogenous gene expression in embryos. (J:126341)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 95 assay results
In Structures Affected by this Mutation: 21 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rspo2 Mutation:  19 strains or lines available
References
Original:  J:126341 Nam JS, et al., Mouse R-spondin2 is required for apical ectodermal ridge maintenance in the hindlimb. Dev Biol. 2007 Nov 1;311(1):124-35
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory